A Linear Model for Transcription Factor Binding Affinity Prediction in Protein Binding Microarrays
نویسندگان
چکیده
منابع مشابه
A Linear Model for Transcription Factor Binding Affinity Prediction in Protein Binding Microarrays
Protein binding microarrays (PBM) are a high throughput technology used to characterize protein-DNA binding. The arrays measure a protein's affinity toward thousands of double-stranded DNA sequences at once, producing a comprehensive binding specificity catalog. We present a linear model for predicting the binding affinity of a protein toward DNA sequences based on PBM data. Our model represent...
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MOTIVATION Prediction of transcription factor binding sites (TFBSs) is crucial for promoter modeling and network inference. Quality of the predictions is spoiled by numerous false positives, which persist as the main problem for all presently available TFBS search methods. RESULTS We suggest a novel approach, which is alternative to widely used position weight matrices (PWMs) and Hidden Marko...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0020059